P-191 The impact of resveratrol supplementation as antioxidant on embryonic development in older women (over 40years) undergoing IVF

Abstract Study question Does the resveratrol supplementation in human embryo culture medium improve quality and pregnancy outcomes older women? Summary answer Resveratrol significantly improved good rates. These results are thought to be due biological activities of as an antioxidant. What is known already Reproductive aging involves age-related declines ovarian function development capacity. After initiating meiosis, germ cells arrest at dictyate stage prophase I ovary for 10-50 years women. Accumulated reactive oxygen species (ROS) affect oocytes adversely. Antioxidants reduce ROS-induced damage important antioxidant polyphenolic compound. has positive effects on fertility, it improves blastocysts aged animal could enhance maturation from However, there just a few studies clarified relationship between embryos design, size, duration The study retrospectively included 966 patients with over 40 evaluate impact IVF January 2019 December 2021. Participants/materials, setting, methods female (over 40years) were divided into 2 groups, fertilized cultured MRC media (MRC#D13 (day 1 ∼ 3) MRC#D46 4 6 medium); Maria Medical Foundation, South Korea) presence or absence (0.5 μM; Sigma-Aldrich, USA). Fertilization, embryo, clinical pregnancy, implantation rate after transfer compared among two groups. Data analyzed using SPSS T-test p value <0.05 considered statistically significant. Main role chance There was no significant difference age (42.5 ± 2.2 vs. 42.3 2.0, P = 0.358), No. previous ART cycles (3.6 2.3 3.7 2.5, 0.680), thickness endometrium (9.2 1.5 9.4 1.4, 0.312), per (74.6% 75.8%, 0.290), fertilization (81.5% 80.0%, 0.165), transferred (2.4 0.6 2.4 0.6, 0.818). (44.0% 36.4%, < 0.05) group 7.6% higher than control group. Pregnancy (26.8% 22.7%, 0.167) (11.9% 9.9%, 0.131) slightly but this not Limitations, reasons caution This retrospective that generates strong conclusions, interesting test prospective study. conducted single center. Embryo result based rate, while live birth data all pregnancies yet available. Wider implications findings first investigate embryonic developmental competence potential women 40years). Trial registration number applicable